Currents during the Pharmacy Teaching and you will LearningAsma El-Magboub, Ian S

Currents during the Pharmacy Teaching and you will LearningAsma El-Magboub, Ian S

Currents during the Pharmacy Teaching and you will LearningAsma El-Magboub, Ian S

Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a er der nogen succeshistorier pГҐ SingleSlavic discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physiological aim and pharmacology out of curcumin

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the major part of the brand new yellow dye away from turmeric, a keen Indian spruce that is extracted from the brand new rhizome of one’s warm bush Curcuma longa, which is one of the Zingiberaceae relatives. Inside chapter, we discuss the pharmacological items out-of curcumin and you can explore the latest unit basics of these facts. I upcoming review brand new confirmed and prospective health-related spends out-of curcumin. Curcumin known typically just like the a therapeutic agent, however, its mechanism off step try outlined. The fresh new pharmacological ramifications of curcumin be seemingly the consequence of good synergism out of networks away from poor biochemical relationships that have multiple physical targets for the interrelated signaling routes. These aim is nutrients such cyclooxygenase, lipoxygenase and you may necessary protein kinases, and you will transcription affairs eg NF-?B, STAT and Nrf2. Modulation of these particles impacts downstream affectors that make brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial circumstances out of curcumin. These consequences was basically checked-out from inside the medical trials of curcumin having serious pain and inflammatory ailment, cancers, Alzheimer condition, cardiovascular sickness, and all forms of diabetes. The newest samples have used changeable amounts out of curcuminwith additional wavelengths and you can course, to the general end that large amounts away from curcumin in the level of grams must obtain therapeutic consequences. Find out more

Curcumin: Synthesis, Emerging Role inside the Pain Management and you can Wellness Effects

Guide Chapter Samples of plant-derived pharmaceuticals that have get to be the focus off continuous and you will great look and you will creativity attract keeps, to date, started a bit scarce. After several years, the past twenty years were characterized by good 100-flex upsurge in exactly how many medical content blogged annually you to definitely is regarding benefit to the usage of curcumin into the biomedicine. Find out more

Structure, synthesis and physical circumstances off curcumin prodrugs

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some possible pharmacological outcomes and may enjoys therapeutic applications in lot of situation states, because discussed in detail in the earlier part. not, the potential scientific efficacy regarding curcumin is bound of the their physicochemical services away from poor water solubility and you will imbalance, which trigger lowest bioavailability. Prodrugs off curcumin provide a means to improvement of your own biopharmaceutical and pharmacokinetic properties, and will allow exploitation of your pharmacological outcomes of curcumin. Within part, i first opinion the physicochemical and you may pharmacokinetics regarding curcumin. We next establish the style of curcumin prodrugs with improved drinking water solubility and you may improved agents balance that is certainly translated back to 100 % free curcumin upon bioactivation in the vivo. I focus on previous victory in this area, with a focus on the design, synthesis and you will review away from prodrugs based on promoieties and proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric product eg hyaluronic acidic and you will polyethylene glycol. That it part has the reason for optimisation of your own physicochemical and biopharmaceutical attributes while the physical points out-of curcumin prodrugs, to your mission having fun with of them curcumin derivatives inside clinical programs. Read more

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